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Synthesis and Biological Evaluation of 7-Deoxy-Epothilone Analogues
The synthesis of two deoxygenated analogues of potent epothilones is reported in an effort to analyze the relative importance of molecular conformation and ligand–target interactions to biological activity. 7-deoxy-epothilone D and 7-deoxy-(S)-14-methoxy-epothilone D were prepared through total synt...
Shranjeno v:
| izdano v: | Int J Mol Sci |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
MDPI
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5372660/ https://ncbi.nlm.nih.gov/pubmed/28304361 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18030648 |
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