Understanding tubulin–Taxol interactions: Mutations that impart Taxol binding to yeast tubulin

We have successfully used mutagenesis to engineer Taxol (paclitaxel) binding activity in Saccharomyces cerevisiae tubulin. Taxol, a successful antitumor agent, acts by promoting tubulin assembly and stabilizing microtubules. Several structurally diverse antimitotic compounds, including the epothilon...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Gupta, Mohan L., Bode, Claudia J., Georg, Gunda I., Himes, Richard H.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2003
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164457/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12740436/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1131967100
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