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Understanding tubulin–Taxol interactions: Mutations that impart Taxol binding to yeast tubulin
We have successfully used mutagenesis to engineer Taxol (paclitaxel) binding activity in Saccharomyces cerevisiae tubulin. Taxol, a successful antitumor agent, acts by promoting tubulin assembly and stabilizing microtubules. Several structurally diverse antimitotic compounds, including the epothilon...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2003
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC164457/ https://ncbi.nlm.nih.gov/pubmed/12740436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1131967100 |
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