Understanding tubulin–Taxol interactions: Mutations that impart Taxol binding to yeast tubulin

We have successfully used mutagenesis to engineer Taxol (paclitaxel) binding activity in Saccharomyces cerevisiae tubulin. Taxol, a successful antitumor agent, acts by promoting tubulin assembly and stabilizing microtubules. Several structurally diverse antimitotic compounds, including the epothilon...

Descrición completa

Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Gupta, Mohan L., Bode, Claudia J., Georg, Gunda I., Himes, Richard H.
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164457/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12740436/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1131967100
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!