Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) Inhibitors

The design and synthesis of isoxazole 3 is described, a potent JNK inhibitor with two fold selectivity over p38. Optimization of this scaffold led to compounds 27 and 28 which showed greatly improved selectivity over p38 by maintaining the JNK3 potency of compound 3. Extensive SAR studies will be de...

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Bibliographic Details
Published in:Bioorg Med Chem Lett
Main Authors: He, Yuanjun, Duckett, Derek, Chen, Weimin, Ling, Yuan Yuan, Cameron, Michael D., Lin, Li, Ruiz, Claudia H., LoGrasso, Philip V., Kamenecka, Theodore M., Koenig, Marcel
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540177/
https://ncbi.nlm.nih.gov/pubmed/24332487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.11.052
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