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Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors
A novel series of c-jun N-terminal kinase (JNK) inhibitors were designed and developed from a high-throughput-screening hit. Through the optimization of the piperazine amide 1, several potent compounds were discovered. The X-ray crystal structure of 4g showed a unique binding mode different from oth...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2737472/ https://ncbi.nlm.nih.gov/pubmed/19433357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.03.086 |
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