Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors

A novel series of c-jun N-terminal kinase (JNK) inhibitors were designed and developed from a high-throughput-screening hit. Through the optimization of the piperazine amide 1, several potent compounds were discovered. The X-ray crystal structure of 4g showed a unique binding mode different from oth...

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Hlavní autoři: Shin, Youseung, Chen, Weiming, Habel, Jeff, Duckett, Derek, Ling, Yuan Yuan, Koenig, Marcel, He, Yuanjun, Vojkovsky, Tomas, LoGrasso, Philip, Kamenecka, Theodore M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737472/
https://ncbi.nlm.nih.gov/pubmed/19433357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.03.086
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