Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-Jun N-terminal kinase inhibitors

The design and synthesis of a novel series of c-jun N-terminal kinase (JNK) inhibitors is described. The development of the 4-(pyrazol-3-yl)-pyridine series was discovered from an earlier pyrimidine series of JNK inhibitors. Through the optimization of the scaffold 2, several potent compounds with g...

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Main Authors: Noël, Romain, Shin, Youseung, Song, Xinyi, He, Yuanjun, Koenig, Marcel, Chen, Weimin, Ling, Yuan Yuan, Lin, Li, Ruiz, Claudia H., LoGrasso, Phil, Cameron, Michael D., Duckett, Derek R., Kamenecka, Theodore M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081976/
https://ncbi.nlm.nih.gov/pubmed/21185177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.11.104
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