Synthesis, Biological Evaluation, X-Ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors

Given the significant body of data supporting an essential role for c-jun-N-terminal kinase (JNK) in neurodegenerative disorders, we set out to develop highly selective JNK inhibitors, with good cell potency, and good brain penetration properties. The structure activity relationships (SAR) around a...

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Detalhes bibliográficos
Main Authors: Kamenecka, Ted, Jiang, Rong, Song, Xinyi, Duckett, Derek, Chen, Weimin, Ling, Yuan Yuan, Habel, Jeff, Laughlin, John D., Chambers, Jeremy, Figuera-Losada, Mariana, Cameron, Michael D., Lin, Li, Ruiz, Claudia H., LoGrasso, Philip V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804074/
https://ncbi.nlm.nih.gov/pubmed/19947601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901351f
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