Structure-Activity Relationships and X-ray Structures Describing the Selectivity of Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38

c-Jun N-terminal kinase 3α1 (JNK3α1) is a mitogen-activated protein kinase family member expressed primarily in the brain that phosphorylates protein transcription factors, including c-Jun and activating transcription factor-2 (ATF-2) upon activation by a variety of stress-based stimuli. In this stu...

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Detalhes bibliográficos
Main Authors: Kamenecka, Ted, Habel, Jeff, Duckett, Derek, Chen, Weimin, Ling, Yuan Yuan, Frackowiak, Bozena, Jiang, Rong, Shin, Youseung, Song, Xinyi, LoGrasso, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676016/
https://ncbi.nlm.nih.gov/pubmed/19261605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809430200
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