Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles

Three JNK isoforms, JNK1, JNK2, and JNK3 have been reported and unique biological function has been ascribed to each. It is unknown if selective inhibition of these isoforms would confer therapeutic or safety benefit. To probe JNK isoform function we designed JNK2/3 inhibitors that have >30-fold...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Park, HaJeung, Iqbal, Sarah, Hernandez, Pamela, Mora, Rudy, Zheng, Ke, Feng, Yangbo, LoGrasso, Philip
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306959/
https://ncbi.nlm.nih.gov/pubmed/25623238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08047
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