A Small Molecule Bidentate-Binding Dual Inhibitor Probe of the LRRK2 and JNK Kinases

Both JNK and LRRK2 are associated with Parkinson’s disease (PD). Here we report a reasonably selective and potent kinase inhibitor (compound 6) that bound to both JNK and LRRK2 (a dual inhibitor). A bidentate-binding strategy that simultaneously utilized the ATP hinge binding and a unique protein su...

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Detalhes bibliográficos
Main Authors: Feng, Yangbo, Chambers, Jeremy W., Iqbal, Sarah, Koenig, Marcel, Park, HaJeung, Cherry, Lisa, Hernandez, Pamela, Figuera-Losada, Mariana, LoGrasso, Philip V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759981/
https://ncbi.nlm.nih.gov/pubmed/23751758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb3006165
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