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Selective Inhibition of Mitochondrial JNK Signaling Achieved Using Peptide Mimicry of the Sab Kinase Interacting Motif-1 (KIM1)

The c-jun N-terminal kinases (JNKs) are responsive to stress stimuli leading to activation of proapoptotic proteins and transcription. Additionally, JNK mitochondrial localization has been reported. To selectively target mitochondrial JNK signaling, we exploited JNKs interaction with its mitochondri...

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Detalhes bibliográficos
Main Authors: Chambers, Jeremy W., Cherry, Lisa, Laughlin, John D., Figuera-Losada, Mariana, LoGrasso, Philip V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158843/
https://ncbi.nlm.nih.gov/pubmed/21563797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200062a
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