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Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors
[Image: see text] A novel series of 2-aminopyridopyrimidinone based JNK (c-jun N-terminal kinase) inhibitors were discovered and developed. Structure–activity relationships (SARs) were systematically developed utilizing biochemical and cell based assays and in vitro and in vivo drug metabolism and p...
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| Vydáno v: | ACS Med Chem Lett |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Chemical
Society
2015
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4394340/ https://ncbi.nlm.nih.gov/pubmed/25893042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500474d |
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