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Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors
[Image: see text] A novel series of 2-aminopyridopyrimidinone based JNK (c-jun N-terminal kinase) inhibitors were discovered and developed. Structure–activity relationships (SARs) were systematically developed utilizing biochemical and cell based assays and in vitro and in vivo drug metabolism and p...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | ACS Med Chem Lett |
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| Κύριοι συγγραφείς: | , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Chemical
Society
2015
|
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4394340/ https://ncbi.nlm.nih.gov/pubmed/25893042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500474d |
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