Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors

[Image: see text] A novel series of 2-aminopyridopyrimidinone based JNK (c-jun N-terminal kinase) inhibitors were discovered and developed. Structure–activity relationships (SARs) were systematically developed utilizing biochemical and cell based assays and in vitro and in vivo drug metabolism and p...

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Détails bibliographiques
Publié dans:ACS Med Chem Lett
Auteurs principaux: Zheng, Ke, Park, Chul Min, Iqbal, Sarah, Hernandez, Pamela, Park, HaJeung, LoGrasso, Philip V., Feng, Yangbo
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2015
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394340/
https://ncbi.nlm.nih.gov/pubmed/25893042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500474d
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