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A Small Molecule Bidentate-Binding Dual Inhibitor Probe of the LRRK2 and JNK Kinases
Both JNK and LRRK2 are associated with Parkinson’s disease (PD). Here we report a reasonably selective and potent kinase inhibitor (compound 6) that bound to both JNK and LRRK2 (a dual inhibitor). A bidentate-binding strategy that simultaneously utilized the ATP hinge binding and a unique protein su...
Gorde:
| Egile Nagusiak: | , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2013
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3759981/ https://ncbi.nlm.nih.gov/pubmed/23751758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb3006165 |
| Etiketak: |
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