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Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles
Three JNK isoforms, JNK1, JNK2, and JNK3 have been reported and unique biological function has been ascribed to each. It is unknown if selective inhibition of these isoforms would confer therapeutic or safety benefit. To probe JNK isoform function we designed JNK2/3 inhibitors that have >30-fold...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4306959/ https://ncbi.nlm.nih.gov/pubmed/25623238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08047 |
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