Synthesis, Biological Evaluation, X-Ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors

Given the significant body of data supporting an essential role for c-jun-N-terminal kinase (JNK) in neurodegenerative disorders, we set out to develop highly selective JNK inhibitors, with good cell potency, and good brain penetration properties. The structure activity relationships (SAR) around a...

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Hlavní autoři: Kamenecka, Ted, Jiang, Rong, Song, Xinyi, Duckett, Derek, Chen, Weimin, Ling, Yuan Yuan, Habel, Jeff, Laughlin, John D., Chambers, Jeremy, Figuera-Losada, Mariana, Cameron, Michael D., Lin, Li, Ruiz, Claudia H., LoGrasso, Philip V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804074/
https://ncbi.nlm.nih.gov/pubmed/19947601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901351f
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