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Synthesis, Biological Evaluation, X-Ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors

Given the significant body of data supporting an essential role for c-jun-N-terminal kinase (JNK) in neurodegenerative disorders, we set out to develop highly selective JNK inhibitors, with good cell potency, and good brain penetration properties. The structure activity relationships (SAR) around a...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Kamenecka, Ted, Jiang, Rong, Song, Xinyi, Duckett, Derek, Chen, Weimin, Ling, Yuan Yuan, Habel, Jeff, Laughlin, John D., Chambers, Jeremy, Figuera-Losada, Mariana, Cameron, Michael D., Lin, Li, Ruiz, Claudia H., LoGrasso, Philip V.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804074/
https://ncbi.nlm.nih.gov/pubmed/19947601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901351f
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