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Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) Inhibitors
The design and synthesis of isoxazole 3 is described, a potent JNK inhibitor with two fold selectivity over p38. Optimization of this scaffold led to compounds 27 and 28 which showed greatly improved selectivity over p38 by maintaining the JNK3 potency of compound 3. Extensive SAR studies will be de...
Shranjeno v:
| izdano v: | Bioorg Med Chem Lett |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4540177/ https://ncbi.nlm.nih.gov/pubmed/24332487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.11.052 |
| Oznake: |
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