The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes

BACKGROUND: Newborns and young infants are at higher risk for infections than adults, and manifest suboptimal vaccine responses, motivating a search for novel immunomodulators and/or vaccine adjuvants effective in early life. In contrast to most TLR agonists (TLRA), TLR8 agonists such as imidazoquin...

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Vydáno v:PLoS One
Hlavní autoři: Ganapathi, Lakshmi, Van Haren, Simon, Dowling, David J., Bergelson, Ilana, Shukla, Nikunj M., Malladi, Subbalakshmi S., Balakrishna, Rajalakshmi, Tanji, Hiromi, Ohto, Umeharu, Shimizu, Toshiyuki, David, Sunil A., Levy, Ofer
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537157/
https://ncbi.nlm.nih.gov/pubmed/26274907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134640
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