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Preliminary Evaluation of a 3H Imidazoquinoline Library as Dual TLR7/TLR8 Antagonists

Toll-like receptors (TLR) -7 and -8 are thought to play an important role in immune activation processes underlying the pathophysiology of HIV and several clinically important autoimmune diseases. Based on our earlier findings of TLR7-antagonistic activity in a 3H imidazoquinoline, we sought to exam...

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書目詳細資料
Main Authors: Shukla, Nikunj M., Malladi, Subbalakshmi S., Day, Victor, David, Sunil A.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114175/
https://ncbi.nlm.nih.gov/pubmed/21620714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.04.052
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