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Structure-based Ligand Design of Novel Human Toll-like Receptor 8 Agonists
Toll-like receptor (TLR)-8 agonists activate adaptive immune responses by inducing robust production of T helper 1-polarizing cytokines, suggesting that TLR8-active compounds may be promising candidate adjuvants. We recently reported pure TLR8 agonistic activity in a C2-butyl furo[2,3-c]quinoline. W...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4105021/ https://ncbi.nlm.nih.gov/pubmed/24474703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300573 |
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