Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure–Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds

[Image: see text] Toll-like receptor (TLR) 7 and 8 agonists are potential vaccine adjuvants, since they directly activate APCs and enhance Th1-driven immune responses. Previous SAR investigations in several scaffolds of small molecule TLR7/8 activators pointed to the strict dependence of the selecti...

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Detalhes bibliográficos
Main Authors: Yoo, Euna, Salunke, Deepak B., Sil, Diptesh, Guo, Xiaoqiang, Salyer, Alex C. D., Hermanson, Alec R., Kumar, Manoj, Malladi, Subbalakshmi S., Balakrishna, Rajalakshmi, Thompson, Ward H., Tanji, Hiromi, Ohto, Umeharu, Shimizu, Toshiyuki, David, Sunil A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191598/
https://ncbi.nlm.nih.gov/pubmed/25192394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500744f
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