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Exquisite Selectivity For Human Toll-like Receptor 8 in Substituted Furo[2,3-c]quinolines
Toll-like receptor (TLR)-8 agonists activate adaptive immune responses by inducing robust production of T helper 1-polarizing cytokines, suggesting that TLR8-active compounds may be promising candidate adjuvants. We synthesized and evaluated hitherto unexplored furo[2,3-c]quinolines and its regioiso...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3790333/ https://ncbi.nlm.nih.gov/pubmed/23899291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400694d |
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