Exquisite Selectivity For Human Toll-like Receptor 8 in Substituted Furo[2,3-c]quinolines

Toll-like receptor (TLR)-8 agonists activate adaptive immune responses by inducing robust production of T helper 1-polarizing cytokines, suggesting that TLR8-active compounds may be promising candidate adjuvants. We synthesized and evaluated hitherto unexplored furo[2,3-c]quinolines and its regioiso...

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Main Authors: Kokatla, Hari Prasad, Sil, Diptesh, Malladi, Subbalakshmi S., Balakrishna, Rajalakshmi, Hermanson, Alec R., Fox, Lauren M., Wang, Xinkun, Dixit, Anshuman, David, Sunil A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790333/
https://ncbi.nlm.nih.gov/pubmed/23899291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400694d
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