SAR refinement of antileishmanial N(2),N(4)-disubstituted quinazoline-2,4-diamines

Visceral leishmaniasis is a neglected parasitic disease that has a high fatality rate in the absence of treatment. New drugs that are inexpensive, orally active, and effective could be useful tools in the fight against this disease. We previously showed that N(2),N(4)-disubstituted quinazoline-2,4-d...

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Veröffentlicht in:Bioorg Med Chem
Hauptverfasser: Zhu, Xiaohua, Van Horn, Kurt S., Barber, Megan, Yang, Sihyung, Wang, Michael Zhuo, Manetsch, Roman, Werbovetz, Karl A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536136/
https://ncbi.nlm.nih.gov/pubmed/25749014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.02.020
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