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Elucidation of Vasodilation Response and Structure Activity Relationships of N(2),N(4)-Disubstituted Quinazoline 2,4-Diamines in a Rat Pulmonary Artery Model

Pulmonary arterial hypertension (PAH) is a rare and progressive disease arising from various etiologies and pathogenesis. PAH decreases life expectancy due to pulmonary vascular remodeling, elevation of mean pulmonary arterial pressure, and ultimately progresses to heart failure. While clinical trea...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Paracha, Tamkeen Urooj, Pobsuk, Nattakarn, Salaloy, Nattapas, Suphakun, Praphasri, Pekthong, Dumrongsak, Hannongbua, Supa, Choowongkomon, Kiattawee, Khorana, Nantaka, Temkitthawon, Prapapan, Ingkaninan, Kornkanok, Gleeson, M. Paul, Chootip, Krongkarn
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358775/
https://ncbi.nlm.nih.gov/pubmed/30646523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24020281
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