Elucidation of Vasodilation Response and Structure Activity Relationships of N(2),N(4)-Disubstituted Quinazoline 2,4-Diamines in a Rat Pulmonary Artery Model

Pulmonary arterial hypertension (PAH) is a rare and progressive disease arising from various etiologies and pathogenesis. PAH decreases life expectancy due to pulmonary vascular remodeling, elevation of mean pulmonary arterial pressure, and ultimately progresses to heart failure. While clinical trea...

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Pubblicato in:Molecules
Autori principali: Paracha, Tamkeen Urooj, Pobsuk, Nattakarn, Salaloy, Nattapas, Suphakun, Praphasri, Pekthong, Dumrongsak, Hannongbua, Supa, Choowongkomon, Kiattawee, Khorana, Nantaka, Temkitthawon, Prapapan, Ingkaninan, Kornkanok, Gleeson, M. Paul, Chootip, Krongkarn
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358775/
https://ncbi.nlm.nih.gov/pubmed/30646523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24020281
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