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SAR study on N(2),N(4)-disubstituted pyrimidine-2,4-diamines as effective CDK2/CDK9 inhibitors and antiproliferative agents
Cyclin-dependent kinases (CDKs) are pivotal kinases in cell cycle transition and gene transcription. A series of N(2),N(4)-diphenylpyrimidine-2,4-diamines were previously identified as potent CDK2/CDK9 inhibitors. To explore the SAR of this structural prototype, twenty-four novel N(2),N(4)-disubstit...
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| Опубликовано в: : | RSC Adv |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Royal Society of Chemistry
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5890689/ https://ncbi.nlm.nih.gov/pubmed/29682280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8ra01440j |
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