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Substrate–Protein Interaction in Human Tryptophan Dioxygenase: The Critical Role of H76
The initial and rate-limiting step of the kynurenine pathway in humans involves the oxidation of tryptophan to N-formyl kynurenine catalyzed by two hemeproteins, tryptophan 2,3-dioxygenase (hTDO) and indoleamine 2,3-dioxygenase (hIDO). In hTDO, the conserved H76 residue is believed to act as an acti...
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| Publicado en: | J Am Chem Soc |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4535339/ https://ncbi.nlm.nih.gov/pubmed/19209904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja807969a |
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