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Substrate–Protein Interaction in Human Tryptophan Dioxygenase: The Critical Role of H76

The initial and rate-limiting step of the kynurenine pathway in humans involves the oxidation of tryptophan to N-formyl kynurenine catalyzed by two hemeproteins, tryptophan 2,3-dioxygenase (hTDO) and indoleamine 2,3-dioxygenase (hIDO). In hTDO, the conserved H76 residue is believed to act as an acti...

詳細記述

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書誌詳細
出版年:J Am Chem Soc
主要な著者: Batabyal, Dipanwita, Yeh, Syun-Ru
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4535339/
https://ncbi.nlm.nih.gov/pubmed/19209904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja807969a
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