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Substrate–Protein Interaction in Human Tryptophan Dioxygenase: The Critical Role of H76

The initial and rate-limiting step of the kynurenine pathway in humans involves the oxidation of tryptophan to N-formyl kynurenine catalyzed by two hemeproteins, tryptophan 2,3-dioxygenase (hTDO) and indoleamine 2,3-dioxygenase (hIDO). In hTDO, the conserved H76 residue is believed to act as an acti...

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Dades bibliogràfiques
Publicat a:J Am Chem Soc
Autors principals: Batabyal, Dipanwita, Yeh, Syun-Ru
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4535339/
https://ncbi.nlm.nih.gov/pubmed/19209904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja807969a
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