Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase

Tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) play a central role in tryptophan metabolism and are involved in many cellular and disease processes. Here we report the crystal structure of human TDO (hTDO) in a ternary complex with the substrates L-Trp and O(2) and in a binar...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lewis-Ballester, Ariel, Forouhar, Farhad, Kim, Sung-Mi, Lew, Scott, Wang, YongQiang, Karkashon, Shay, Seetharaman, Jayaraman, Batabyal, Dipanwita, Chiang, Bing-Yu, Hussain, Munif, Correia, Maria Almira, Yeh, Syun-Ru, Tong, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5071832/
https://ncbi.nlm.nih.gov/pubmed/27762317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35169
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