Structural basis for retroviral integration into nucleosomes

Retroviral integration is catalyzed by a tetramer of integrase (IN) assembled on viral DNA ends in a stable complex, known as the intasome(1,2). How the intasome interfaces with chromosomal DNA, which exists in the form of nucleosomal arrays, is currently unknown. Here we show that the prototype foa...

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Udgivet i:Nature
Main Authors: Maskell, Daniel P., Renault, Ludovic, Serrao, Erik, Lesbats, Paul, Matadeen, Rishi, Hare, Stephen, Lindemann, Dirk, Engelman, Alan N., Costa, Alessandro, Cherepanov, Peter
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530500/
https://ncbi.nlm.nih.gov/pubmed/26061770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14495
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