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Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer
Retroviral integrase can efficiently utilise nucleosomes for insertion of the reverse-transcribed viral DNA. In face of the structural constraints imposed by the nucleosomal structure, integrase gains access to the scissile phosphodiester bonds by lifting DNA off the histone octamer at the site of i...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6744463/ https://ncbi.nlm.nih.gov/pubmed/31519882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12007-w |
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