Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer

Retroviral integrase can efficiently utilise nucleosomes for insertion of the reverse-transcribed viral DNA. In face of the structural constraints imposed by the nucleosomal structure, integrase gains access to the scissile phosphodiester bonds by lifting DNA off the histone octamer at the site of i...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Wilson, Marcus D., Renault, Ludovic, Maskell, Daniel P., Ghoneim, Mohamed, Pye, Valerie E., Nans, Andrea, Rueda, David S., Cherepanov, Peter, Costa, Alessandro
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744463/
https://ncbi.nlm.nih.gov/pubmed/31519882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12007-w
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