Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer

Retroviral integrase can efficiently utilise nucleosomes for insertion of the reverse-transcribed viral DNA. In face of the structural constraints imposed by the nucleosomal structure, integrase gains access to the scissile phosphodiester bonds by lifting DNA off the histone octamer at the site of i...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Wilson, Marcus D., Renault, Ludovic, Maskell, Daniel P., Ghoneim, Mohamed, Pye, Valerie E., Nans, Andrea, Rueda, David S., Cherepanov, Peter, Costa, Alessandro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744463/
https://ncbi.nlm.nih.gov/pubmed/31519882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12007-w
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