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Structural basis for retroviral integration into nucleosomes
Retroviral integration is catalyzed by a tetramer of integrase (IN) assembled on viral DNA ends in a stable complex, known as the intasome(1,2). How the intasome interfaces with chromosomal DNA, which exists in the form of nucleosomal arrays, is currently unknown. Here we show that the prototype foa...
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| 出版年: | Nature |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4530500/ https://ncbi.nlm.nih.gov/pubmed/26061770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14495 |
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