Structural basis for retroviral integration into nucleosomes

Retroviral integration is catalyzed by a tetramer of integrase (IN) assembled on viral DNA ends in a stable complex, known as the intasome(1,2). How the intasome interfaces with chromosomal DNA, which exists in the form of nucleosomal arrays, is currently unknown. Here we show that the prototype foa...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nature
Egile Nagusiak: Maskell, Daniel P., Renault, Ludovic, Serrao, Erik, Lesbats, Paul, Matadeen, Rishi, Hare, Stephen, Lindemann, Dirk, Engelman, Alan N., Costa, Alessandro, Cherepanov, Peter
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530500/
https://ncbi.nlm.nih.gov/pubmed/26061770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14495
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