Structural basis for spumavirus GAG tethering to chromatin

The interactions between a retrovirus and host cell chromatin that underlie integration and provirus expression are poorly understood. The prototype foamy virus (PFV) structural protein GAG associates with chromosomes via a chromatin-binding sequence (CBS) located within its C-terminal region. Here,...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Lesbats, Paul, Serrao, Erik, Maskell, Daniel P., Pye, Valerie E., O’Reilly, Nicola, Lindemann, Dirk, Engelman, Alan N., Cherepanov, Peter
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448199/
https://ncbi.nlm.nih.gov/pubmed/28490494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621159114
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