Structural basis for retroviral integration into nucleosomes

Retroviral integration is catalyzed by a tetramer of integrase (IN) assembled on viral DNA ends in a stable complex, known as the intasome(1,2). How the intasome interfaces with chromosomal DNA, which exists in the form of nucleosomal arrays, is currently unknown. Here we show that the prototype foa...

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Gepubliceerd in:Nature
Hoofdauteurs: Maskell, Daniel P., Renault, Ludovic, Serrao, Erik, Lesbats, Paul, Matadeen, Rishi, Hare, Stephen, Lindemann, Dirk, Engelman, Alan N., Costa, Alessandro, Cherepanov, Peter
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530500/
https://ncbi.nlm.nih.gov/pubmed/26061770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14495
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