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Transcriptional repression by PRC1 in the absence of H2A monoubiquitylation

Histone H2A monoubiquitylation (H2Aub) is considered to be a key effector in transcriptional repression by Polycomb-repressive complex 1 (PRC1). We analyzed Drosophila with a point mutation in the PRC1 subunit Sce that abolishes its H2A ubiquitylase activity or with point mutations in the H2A and H2...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Pengelly, Ana Raquel, Kalb, Reinhard, Finkl, Katja, Müller, Jürg
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526733/
https://ncbi.nlm.nih.gov/pubmed/26178786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.265439.115
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