PRC2 directly methylates GATA4 and represses its transcriptional activity

Polycomb-repressive complex 2 (PRC2) promotes tissue-specific differentiation by depositing trimethylated histone H3 Lys 27 (H3K27me3) epigenetic marks to silence ectopic gene expression programs. Here, we show that EZH2, the catalytic subunit of PRC2, is required for cardiac morphogenesis. Both in...

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書誌詳細
主要な著者: He, Aibin, Shen, Xiaohua, Ma, Qing, Cao, Jingjing, von Gise, Alexander, Zhou, Pingzhu, Wang, Gang, Marquez, Victor E., Orkin, Stuart H., Pu, William T.
フォーマット: Artigo
言語:Inglês
出版事項: Cold Spring Harbor Laboratory Press 2012
主題:
Research Communication
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258964/
https://ncbi.nlm.nih.gov/pubmed/22215809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.173930.111
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