PRC2 directly methylates GATA4 and represses its transcriptional activity

Polycomb-repressive complex 2 (PRC2) promotes tissue-specific differentiation by depositing trimethylated histone H3 Lys 27 (H3K27me3) epigenetic marks to silence ectopic gene expression programs. Here, we show that EZH2, the catalytic subunit of PRC2, is required for cardiac morphogenesis. Both in...

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Detalhes bibliográficos
Main Authors: He, Aibin, Shen, Xiaohua, Ma, Qing, Cao, Jingjing, von Gise, Alexander, Zhou, Pingzhu, Wang, Gang, Marquez, Victor E., Orkin, Stuart H., Pu, William T.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258964/
https://ncbi.nlm.nih.gov/pubmed/22215809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.173930.111
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