PRMT5-mediated histone arginine methylation antagonizes transcriptional repression by polycomb complex PRC2

Protein arginine methyltransferase 5 (PRMT5) catalyzes the symmetric di-methylation of arginine residues in histones H3 and H4, marks that are generally associated with transcriptional repression. However, we found that PRMT5 inhibition or depletion led to more genes being downregulated than upregul...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Liu, Fan, Xu, Ye, Lu, Xiaoqing, Hamard, Pierre-Jacques, Karl, Daniel L, Man, Na, Mookhtiar, Adnan K, Martinez, Concepcion, Lossos, Izidore S, Sun, Jun, Nimer, Stephen D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Gene regulation, Chromatin and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102951/
https://ncbi.nlm.nih.gov/pubmed/32025719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa065
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