PRMT5 regulates DNA repair by controlling the alternative splicing of key histone-modifying enzymes

Protein arginine methyltransferase 5 (PRMT5) is overexpressed in many cancer types and is a promising therapeutic target for several of them, including leukemia and lymphoma. However, we and others have reported that PRMT5 is essential for normal physiology. This dependence may become dose-limiting...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Hamard, Pierre-Jacques, Santiago, Gabriel E., Liu, Fan, Karl, Daniel L., Martinez, Concepcion, Man, Na, Mookhtiar, Adnan K., Duffort, Stephanie, Greenblatt, Sarah, Verdun, Ramiro E., Nimer, Stephen D.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322662/
https://ncbi.nlm.nih.gov/pubmed/30184499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.08.002
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