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PRMT5 regulates DNA repair by controlling the alternative splicing of key histone-modifying enzymes
Protein arginine methyltransferase 5 (PRMT5) is overexpressed in many cancer types and is a promising therapeutic target for several of them, including leukemia and lymphoma. However, we and others have reported that PRMT5 is essential for normal physiology. This dependence may become dose-limiting...
Enregistré dans:
| Publié dans: | Cell Rep |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6322662/ https://ncbi.nlm.nih.gov/pubmed/30184499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.08.002 |
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