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Regulation of Alternative Splicing by Histone Modifications

Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet its regulation is poorly understood. We demonstrated a direct role for histone modifications in alternative splicing. We found distinctive histone modification signatures that correlate with the splicing out...

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Bibliographic Details
Main Authors: Luco, Reini F., Pan, Qun, Tominaga, Kaoru, Blencowe, Benjamin J., Pereira-Smith, Olivia M., Misteli, Tom
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913848/
https://ncbi.nlm.nih.gov/pubmed/20133523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1184208
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