PRMT5-mediated histone arginine methylation antagonizes transcriptional repression by polycomb complex PRC2

Protein arginine methyltransferase 5 (PRMT5) catalyzes the symmetric di-methylation of arginine residues in histones H3 and H4, marks that are generally associated with transcriptional repression. However, we found that PRMT5 inhibition or depletion led to more genes being downregulated than upregul...

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Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Liu, Fan, Xu, Ye, Lu, Xiaoqing, Hamard, Pierre-Jacques, Karl, Daniel L, Man, Na, Mookhtiar, Adnan K, Martinez, Concepcion, Lossos, Izidore S, Sun, Jun, Nimer, Stephen D
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2020
Ämnen:
Gene regulation, Chromatin and Epigenetics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102951/
https://ncbi.nlm.nih.gov/pubmed/32025719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa065
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