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PRMT5-mediated histone arginine methylation antagonizes transcriptional repression by polycomb complex PRC2
Protein arginine methyltransferase 5 (PRMT5) catalyzes the symmetric di-methylation of arginine residues in histones H3 and H4, marks that are generally associated with transcriptional repression. However, we found that PRMT5 inhibition or depletion led to more genes being downregulated than upregul...
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| 出版年: | Nucleic Acids Res |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7102951/ https://ncbi.nlm.nih.gov/pubmed/32025719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa065 |
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