PRC2 directly methylates GATA4 and represses its transcriptional activity

Polycomb-repressive complex 2 (PRC2) promotes tissue-specific differentiation by depositing trimethylated histone H3 Lys 27 (H3K27me3) epigenetic marks to silence ectopic gene expression programs. Here, we show that EZH2, the catalytic subunit of PRC2, is required for cardiac morphogenesis. Both in...

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Autores principales: He, Aibin, Shen, Xiaohua, Ma, Qing, Cao, Jingjing, von Gise, Alexander, Zhou, Pingzhu, Wang, Gang, Marquez, Victor E., Orkin, Stuart H., Pu, William T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2012
Materias:
Research Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258964/
https://ncbi.nlm.nih.gov/pubmed/22215809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.173930.111
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