PRC2 directly methylates GATA4 and represses its transcriptional activity

Polycomb-repressive complex 2 (PRC2) promotes tissue-specific differentiation by depositing trimethylated histone H3 Lys 27 (H3K27me3) epigenetic marks to silence ectopic gene expression programs. Here, we show that EZH2, the catalytic subunit of PRC2, is required for cardiac morphogenesis. Both in...

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Main Authors: He, Aibin, Shen, Xiaohua, Ma, Qing, Cao, Jingjing, von Gise, Alexander, Zhou, Pingzhu, Wang, Gang, Marquez, Victor E., Orkin, Stuart H., Pu, William T.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Research Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258964/
https://ncbi.nlm.nih.gov/pubmed/22215809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.173930.111
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