Nalaganje...

PRC2 directly methylates GATA4 and represses its transcriptional activity

Polycomb-repressive complex 2 (PRC2) promotes tissue-specific differentiation by depositing trimethylated histone H3 Lys 27 (H3K27me3) epigenetic marks to silence ectopic gene expression programs. Here, we show that EZH2, the catalytic subunit of PRC2, is required for cardiac morphogenesis. Both in...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: He, Aibin, Shen, Xiaohua, Ma, Qing, Cao, Jingjing, von Gise, Alexander, Zhou, Pingzhu, Wang, Gang, Marquez, Victor E., Orkin, Stuart H., Pu, William T.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258964/
https://ncbi.nlm.nih.gov/pubmed/22215809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.173930.111
Oznake: Označite
Brez oznak, prvi označite!