PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer

Small cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis. Expression array analysis of 23 SCLC cases and 42 normal tissues revealed that EZH2 and other PRC2 members were highly expressed in SCLC. ChIP-seq for H3K27me3 suggested that genes with H3K27me3(+) in SCLC were extended n...

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Detalhes bibliográficos
Main Authors: Sato, Teruyuki, Kaneda, Atsushi, Tsuji, Shingo, Isagawa, Takayuki, Yamamoto, Shogo, Fujita, Takanori, Yamanaka, Ryota, Tanaka, Yukiko, Nukiwa, Toshihiro, Marquez, Victor E., Ishikawa, Yuichi, Ichinose, Masakazu, Aburatani, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665955/
https://ncbi.nlm.nih.gov/pubmed/23714854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01911
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