Activation of Bmp2-Smad1 Signal and Its Regulation by Coordinated Alteration of H3K27 Trimethylation in Ras-Induced Senescence

Cellular senescence involves epigenetic alteration, e.g. loss of H3K27me3 in Ink4a-Arf locus. Using mouse embryonic fibroblast (MEF), we here analyzed transcription and epigenetic alteration during Ras-induced senescence on genome-wide scale by chromatin immunoprecipitation (ChIP)-sequencing and mic...

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Detalhes bibliográficos
Main Authors: Kaneda, Atsushi, Fujita, Takanori, Anai, Motonobu, Yamamoto, Shogo, Nagae, Genta, Morikawa, Masato, Tsuji, Shingo, Oshima, Masanobu, Miyazono, Kohei, Aburatani, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207904/
https://ncbi.nlm.nih.gov/pubmed/22072987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002359
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