An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes

Cancers are characterized by non-random, chromosome copy number alterations that presumably contain oncogenes and tumor–suppressor genes (TSGs). The affected loci are often large, making it difficult to pinpoint which genes are driving the cancer. Here, we report a cross-species in vivo screen of 84...

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Pubblicato in:Nat Genet
Autori principali: Mohankumar, Kumarasamypet M., Currle, David S., White, Elsie, Boulos, Nidal, Dapper, Jason, Eden, Christopher, Nimmervoll, Birgit, Thiruvenkatam, Radhika, Connelly, Michele, Kranenburg, Tanya A., Neale, Geoffrey, Olsen, Scott, Wang, Yong-Dong, Finkelstein, David, Wright, Karen, Gupta, Kirti, Ellison, David W., Thomas, Arzu Onar, Gilbertson, Richard J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520751/
https://ncbi.nlm.nih.gov/pubmed/26075792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3323
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