An integrated in vitro and in vivo high throughput screen identifies treatment leads for ependymoma

Using a mouse model of ependymoma—a chemoresistant brain tumor—we combined multi-cell high-throughput screening (HTS), kinome-wide binding assays, and in vivo efficacy studies, to identify potential treatments with predicted toxicity against neural stem cells (NSC). We identified kinases within the...

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Bibliografski detalji
Glavni autori: Atkinson, Jennifer M., Shelat, Anang A., Carcaboso, Angel Montero, Kranenburg, Tanya A., Arnold, Alexander, Boulos, Nidal, Wright, Karen, Johnson, Robert A., Poppleton, Helen, Mohankumar, Kumarasamypet M., Feau, Clementine, Phoenix, Timothy, Gibson, Paul, Zhu, Liqin, Tong, Yiai, Eden, Chris, Ellison, David W., Priebe, Waldemar, Koul, Dimpy, Yung, W. K. Alfred, Gajjar, Amar, Stewart, Clinton F., Guy, R. Kip, Gilbertson, Richard J.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172881/
https://ncbi.nlm.nih.gov/pubmed/21907928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.08.013
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